Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 5-Chloro-2-(trifluoromethyl)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Trifluoroacetamidine | HCID 2776882 | — |
| 반응물 | 2-Chloro-1,3-bis(dimethylamino)trimethinium hexafluorophosphate | HCID 10590807 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 5-Chloro-2-(trifluoromethyl)pyrimidine | HCID 33697960 | — |
반응 단계
To a solution of 38 mmol trifluoroacetamidine in 70 ml acetonitrile was added 37.92 mmol ((Z)-2-Chloro-3-dimethylamino-allylidene)-dimethyl-ammonium hexafluoro phosphate (CAS: 291756-76-8) followed by 45.5 mmol triethylamine. The yellow solution was stirred at room temperature for 5 hours, then poured onto water and extracted 3 times with ether. The combined extracts were dried over sodium sulfate, filtered and distilled at 760 mm Hg to provide the title compound. MS (m/e): 182.2 (M+, 100%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07605163B2 |
| 출처 데이터셋 | uspto-grants-2009_10 |
| ORD ID | ord-8e32d76e7a374e029d414050280da187 |
| 출처 메모 | uspto-grants-2009_10 |