Formic Acid → 6-Bromo-4-azabenzimidazole

반응식

[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[CH:10](O)=O>>[Br:1][C:2]1[CH:3]=[C:4]2[N:9]=[CH:10][NH:8][C:5]2=[N:6][CH:7]=1

참가 물질

반응물 2

HCID 284Formic Acid

HCID 6911565-Bromopyridine-2,3-diamine

생성물 1

HCID 9115786-Bromo-4-azabenzimidazole

실험 절차

5-Bromo-2,3-diaminopyridine (1.69 g, 8.99 mmole) was taken up in 96% formic acid (50 mL) and heated to reflux. After 18 hr the mixture was cooled to RT and concentrated. The residue was taken up in H2O and the pH was adjusted to 7 with 2.0 M NaOH. The title compound (1.54 g, 87%) was collected as a solid by filtration, washed with H2O, and dried in vacuo: MS (ES) m/e 198/200 (M+H)+.

후처리

temperatureheated to reflux
concentrationconcentrated
filtrationThe title compound (1.54 g, 87%) was collected as a solid by filtration
washwashed with H2O
customdried in vacuo

출처 및 근거

ORD 기록: ord-927531f2479049d7b1a9c998d4269d4f
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07741339B2

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