N-Methylbenzylamine → N-benzyl-(3-methoxy-4-nitro-benzyl)-methyl-amine

반응식

[CH3:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:10][O:11][C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][C:19]=1[N+:20]([O-:22])=[O:21])[CH2:15]Br>>[CH2:3]([N:2]([CH3:1])[CH2:15][C:14]1[CH:17]=[CH:18][C:19]([N+:20]([O-:22])=[O:21])=[C:12]([O:11][CH3:10])[CH:13]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

반응물 2

HCID 7669N-Methylbenzylamine

HCID 126216043-Methoxy-4-nitrobenzyl bromide

생성물 1

HCID 22046408N-benzyl-(3-methoxy-4-nitro-benzyl)-methyl-amine

실험 절차

A solution of N-methyl-benzyl amine was alkylated with 3-methoxy-4-nitro-benzyl bromide as described above for compound 338. 1H NMR (400 MHz, CDCl3): δ 7.83 (d, J=8.6 Hz, 1H), 7.35 (s, 4H), 7.26 (s, 1H), 7.17 (s, 1H), 7.01 (d, J=7.04 Hz, 1H), 3.97 (s, 3H), 3.55 (s, 4H), 2.22 (s, 3H).

출처 및 근거

ORD 기록: ord-45585fb2b478427d9d8a5727bb47c611
출처 데이터셋: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07608618B2

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