3-[4-(3-Bromo-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester → 3-{4-[3-(4-Ethyl-2-phenoxy-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid

HRID 1822260노트

반응식

HRID 1822260 반응식
C[O:2][C:3](=[O:21])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15](Br)[CH:14]=2)=[CH:8][C:7]=1[CH3:20].[CH2:22]([C:24]1[CH:29]=[CH:28][C:27]([OH:30])=[C:26]([O:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:25]=1)[CH3:23]>>[CH2:22]([C:24]1[CH:29]=[CH:28][C:27]([O:30][C:15]2[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=2)[O:12][C:9]2[CH:10]=[CH:11][C:6]([CH2:5][CH2:4][C:3]([OH:2])=[O:21])=[C:7]([CH3:20])[CH:8]=2)=[C:26]([O:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:25]=1)[CH3:23]

참가 물질

3

반응물 2

HCID 578941923-[4-(3-Bromo-phenoxy)-2-methyl-phenyl]-propionic acid methyl esterHCID 587537954-Ethyl-2-phenoxy-phenol

생성물 1

HCID 113972083-{4-[3-(4-Ethyl-2-phenoxy-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid

실험 절차

The title compound is prepared by reacting the compound of 3-[4-(3-bromo-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester with 4-ethyl-2-phenoxy-phenol as in Example 18 to afford 0.200 g (35%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calculated for C30H28O5 468, found 469 (M+1, 100%).

후처리

  1. customto afford 0.200 g (35%)

출처 및 근거

ORD 기록
ord-11162149b2cd46ba82ca87f44d16c7d2
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07608639B2

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