2-Benzyl-4-ethylphenol → 3-{4-[3-(2-Benzyl-4-ethyl-phenoxy)-5-fluoro-phenoxy]-2-methyl-phenyl}-propionic acid
반응식
C[O:2][C:3](=[O:22])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13]2[CH:18]=[C:17]([F:19])[CH:16]=[C:15](Br)[CH:14]=2)=[CH:8][C:7]=1[CH3:21].[CH2:23]([C:30]1[CH:35]=[C:34]([CH2:36][CH3:37])[CH:33]=[CH:32][C:31]=1[OH:38])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH2:23]([C:30]1[CH:35]=[C:34]([CH2:36][CH3:37])[CH:33]=[CH:32][C:31]=1[O:38][C:15]1[CH:14]=[C:13]([CH:18]=[C:17]([F:19])[CH:16]=1)[O:12][C:9]1[CH:10]=[CH:11][C:6]([CH2:5][CH2:4][C:3]([OH:2])=[O:22])=[C:7]([CH3:21])[CH:8]=1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1참가 물질
3
실험 절차
The title compound is prepared by reacting the compound of 3-[4-(3-bromo-5-fluoro-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester with 2-benzyl-4-ethyl-phenol as in Example 18 to afford 0.040 g (13%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calculated for C31H29O4F 484, found 485 (M+1, 100%).
후처리
- customto afford 0.040 g (13%)