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Cyclohexanemethylamine → HCID 68490108, 화합물

HRID 1822442
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HRID 1822442 반응식
C(OC(NC(C(C)(C)C)C(O)=O)=O)(C)(C)C.[CH:17]1([CH2:23][NH2:24])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1.C(OC(=O)NC(C(=O)NC1[C:47]2[C:42](=[CH:43][CH:44]=[CH:45][CH:46]=2)CC1O)C(C)(C)C)(C)(C)C.ClNC(=O)[O-].C([O:58][C:59]([C:61]1([NH:66][C:67]([CH:69]2[CH2:73][CH:72]([O:74][C:75]3[C:84]4[C:79](=[CH:80][C:81]([O:85][CH3:86])=[CH:82][CH:83]=4)[N:78]=[C:77]([C:87]4[CH:92]=[CH:91][CH:90]=[CH:89][CH:88]=4)[CH:76]=3)[CH2:71][N:70]2[C:93](=[O:113])[NH:94][CH:95]([C:100](=[O:112])NC2C3C(=CC=CC=3)CC2O)C(C)(C)C)=[O:68])[CH2:63][CH:62]1[CH:64]=[CH2:65])=[O:60])C>>[CH:42]1([C@H:95]([NH:94][C:93]([N:70]2[CH2:71][C@H:72]([O:74][C:75]3[C:84]4[C:79](=[CH:80][C:81]([O:85][CH3:86])=[CH:82][CH:83]=4)[N:78]=[C:77]([C:87]4[CH:92]=[CH:91][CH:90]=[CH:89][CH:88]=4)[CH:76]=3)[CH2:73][C@H:69]2[C:67]([NH:66][C@:61]2([C:59]([OH:58])=[O:60])[CH2:63][C@H:62]2[CH:64]=[CH2:65])=[O:68])=[O:113])[C:100](=[O:112])[NH:24][CH2:23][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)[CH2:47][CH2:46][CH2:45][CH2:44][CH2:43]1
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

6

반응물 5

HCID 76688CyclohexanemethylamineHCID 50468592-{[(Tert-butoxy)carbonyl]amino}-3,3-dimethylbutanoic acidHCID 22035886ChlorocarbamateHCID 68488177[1-(2-Hydroxy-indan-1-ylcarbamoyl)-2,2-dimethyl-propyl]-carbamic acid tert.butyl esterHCID 684916281-{[1-[1-(2-Hydroxy-indan-1-ylcarbamoyl)-2,2-dimethyl-propylcarbamoyl]-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester

생성물 1

HCID 68490108HCID 68490108, 화합물

실험 절차

N-(tert-butoxycarbonyl)-L-cyclohexylglycine was attached to the resin as described for the preparation of compound 16 followed by reaction with cyclohexanemethylamine as described for the preparation of 17 and removal of the Boc group as described for 18. The afforded compound was then reacted with the chlorocarbamate achieved from 12 as described for the preparation of 13 which gave the title compound. Purity by HPLC>95%. M+H+752.4.

출처 및 근거

ORD 기록
ord-8b5c2be30c524a52a12ec90b34465e19
출처 데이터셋
uspto-grants-2009_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07608590B2

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