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Water → 1-(3,5-Dichloro-1-methylpyrazol-4-yl)-2-{2-(1-methylcyclohexan-1-yl)-thiazol-4-yl}-2-diethylphosphonoethanone

HRID 1822642
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HRID 1822642 반응식
[Cl:1][C:2]1[C:6]([C:7](Cl)=[O:8])=[C:5]([Cl:10])[N:4]([CH3:11])[N:3]=1.[CH3:12][C:13]1([C:19]2[S:20][CH:21]=[C:22]([CH2:24][P:25](=[O:32])([O:29][CH2:30][CH3:31])[O:26][CH2:27][CH3:28])[N:23]=2)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1.CC(C)([O-])C.[K+].O>O1CCCC1>[Cl:1][C:2]1[C:6]([C:7](=[O:8])[CH:24]([C:22]2[N:23]=[C:19]([C:13]3([CH3:12])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]3)[S:20][CH:21]=2)[P:25]([O:29][CH2:30][CH3:31])([O:26][CH2:27][CH3:28])=[O:32])=[C:5]([Cl:10])[N:4]([CH3:11])[N:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 221694993,5-Dichloro-1-methylpyrazole-4-carbonyl chlorideHCID 23665647Potassium tert-butoxideHCID 54149683Diethyl {2-(1-methylcyclohexan-1-yl)-thiazol-4-yl}methylphosphonate

생성물 1

HCID 536619561-(3,5-Dichloro-1-methylpyrazol-4-yl)-2-{2-(1-methylcyclohexan-1-yl)-thiazol-4-yl}-2-diethylphosphonoethanone수율 19.7%

시약·촉매·용매

1
HCID 8028Tetrahydrofuran용매

실험 절차

0.85 g (4 mmols) of 3,5-dichloro-1-methylpyrazole-4-carboxylic acid chloride and 1.32 g (4 mmols) of diethyl {2-(1-methylcyclohexan-1-yl)-thiazol-4-yl}methylphosphonate were dissolved in 15 ml of dry tetrahydrofuran, and 1.12 g (10 mmols) of potassium t-butoxide was added thereto at room temperature. The reaction mixture was stirred for 1 hour at room temperature, and 20 ml of water was added thereto, and extracted with ethyl acetate. The organic layer was washed with water and saturated saline, and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified through silica gel column chromatography to obtain 0.4 g of the intended 1-(3,5-dichloro-1-methylpyrazol-4-yl)-2-{2-(1-methylcyclohexan-1-yl)-thiazol-4-yl}-2-diethylphosphonoethanone.

후처리

  1. customat room temperature
  2. extractionextracted with ethyl acetate
  3. washThe organic layer was washed with water and saturated saline
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled off under reduced pressure
  6. customThe obtained residue was purified through silica gel column chromatography

출처 및 근거

ORD 기록
ord-a88b913c523945b4b88b842868bfbf6f
출처 데이터셋
uspto-grants-2006_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07037880B2

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