참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 4-Aminoindole | HCID 583431 | — |
| 반응물 | 4-Chloro-6,7-dimethoxyquinoline-3-carboxamide | HCID 22170204 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-(1H-Indol-4-ylamino)-6,7-dimethoxy-3-quinolinecarboxamide | HCID 22170237 | 43% |
반응 단계
A mixture of 4-chloro-6,7-dimethoxy-3-quinolinecarboxamide (0.90 g, 0.34 mmol), 4-aminoindol (0.039 g, 0.23 mmol), sodium acetic (0.020 g, 0.23 mmol) and acetic acid (40 μl) in DMF (0.8 ml) was heated at 100° C. for 4.5 h. After cooling the reaction mixture was diluted with water (20 ml) and made alkaline with 1 M NaOH. The precipitate was isolated by centrifugation, re-suspended in water and centrifuged again. The procedure was repeated twice and the solid material dried to give the title compound (27 mg, 43%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07037925B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_05 |
|---|
| ORD ID | ord-7eddd2fe2d6f4344b6105b1908a3a3c0 |
|---|
| 출처 메모 | uspto-grants-2006_05 |
|---|
