Acetic Acid → 4-(3-Hydroxy-2-methylanilino)-6,7-dimethoxy-3-quinolinecarboxamide

HRID 1822850노트

반응식

HRID 1822850 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]([NH2:18])=[O:17].[NH2:19][C:20]1[C:21]([CH3:27])=[C:22]([OH:26])[CH:23]=[CH:24][CH:25]=1.C(O)(=O)C.C([O-])(O)=O.[Na+]>CN(C=O)C.O>[OH:26][C:22]1[C:21]([CH3:27])=[C:20]([CH:25]=[CH:24][CH:23]=1)[NH:19][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]([NH2:18])=[O:17]

참가 물질

7

반응물 4

HCID 176Acetic AcidHCID 1044482-Amino-o-cresolHCID 516892Sodium BicarbonateHCID 221702044-Chloro-6,7-dimethoxyquinoline-3-carboxamide

생성물 1

HCID 221702874-(3-Hydroxy-2-methylanilino)-6,7-dimethoxy-3-quinolinecarboxamide

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

A mixture of 4-chloro-6,7-dimethoxy-3-quinolinecarboxamide (0.046 g, 0.17 mmol), 3-amino-2-methylphenol (0.032 g, 0.26 mmol) and acetic acid (40 μl) in DMF (0.8 ml) was heated at 100° C. for 1.5 h. After cooling, the mixture was diluted with water (15 ml) and made alkaline with saturated NaHCO3. The title compound, which slowly precipitated was filtered off and dried to give 34 mg (55%).

후처리

  1. temperatureAfter cooling
  2. customThe title compound, which slowly precipitated
  3. filtrationwas filtered off
  4. customdried
  5. customto give 34 mg (55%)

출처 및 근거

ORD 기록
ord-6ac3fe1c14f142949459a367b77b9200
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07037925B2

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