Acetic Acid → 6,7-Dimethoxy-4-[(1-oxo-2,3-dihydro-1H-inden-4-yl)amino]-3-quinolinecarboxamide

참여 물질

역할	이름	HCID	투입량
반응물	Acetic Acid	HCID 176	—
반응물	Sodium Bicarbonate	HCID 516892	—
반응물	4-Chloro-6,7-dimethoxyquinoline-3-carboxamide	HCID 22170204	—
반응물	4-amino-2,3-dihydro-1H-inden-1-one	HCID 22170214	—
용매	Water	HCID 962	—
용매	Dimethylformamide	HCID 6228	—
생성물	6,7-Dimethoxy-4-[(1-oxo-2,3-dihydro-1H-inden-4-yl)amino]-3-quinolinecarboxamide	HCID 22170264	92%

반응 조건

온도	100 °C

반응 단계

A mixture of 4-chloro-6,7-dimethoxy-3-quinolinecarboxamide (0.046 g, 0.17 mmol), 4-amino-1-indanone (0.036 g, 0.24 mmol) and acetic acid (40 μl) in DMF (0.6 ml) was heated at 100° C. for 1 h 45 min. After cooling, the mixture was diluted with water and made alkaline with saturated NaHCO3. The precipitate was collected by filtration, washed with water and dried to give title compound (59 mg, 90%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07037925B2
출처 데이터셋	uspto-grants-2006_05
ORD ID	ord-a08ab8a4132a4a96847310ecd47f69b4
출처 메모	uspto-grants-2006_05