4-Fluoro-2-methylaniline → 4-(4-Fluoro-2-methylanilino)-6-methoxy-3-quinolinecarboxamide

HRID 1822859노트

반응식

HRID 1822859 반응식
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH3:9])[CH:3]=1.[CH3:10][O:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[N:18]=[CH:17][C:16]([C:22]([NH2:24])=[O:23])=[C:15]2Cl.C(O)(=O)C.C(O)C>C(O)C>[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:15]2[C:14]3[C:19](=[CH:20][CH:21]=[C:12]([O:11][CH3:10])[CH:13]=3)[N:18]=[CH:17][C:16]=2[C:22]([NH2:24])=[O:23])=[C:4]([CH3:9])[CH:3]=1

참가 물질

5

반응물 3

HCID 679824-Fluoro-2-methylanilineHCID 18476134Acetic acid ethanolHCID 221702744-Chloro-6-methoxyquinoline-3-carboxamide

생성물 1

HCID 221703694-(4-Fluoro-2-methylanilino)-6-methoxy-3-quinolinecarboxamide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 4-fluoro-2-methylaniline (0.025 mmol), 6-methoxy-4-chloro-3-quinolinecarboxamide (0.025 mmol), 50 μl 20% Acetic acid/Ethanol and 250 μl ethanol was refluxed for four hours. After cooling to room temperature the solvent was removed in vacuu.

후처리

  1. temperaturewas refluxed for four hours
  2. customwas removed in vacuu

출처 및 근거

ORD 기록
ord-101c64c03e9c44128660c91cd299617e
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07037925B2

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