Sulfuric Acid → HCID 10336428, 화합물

HRID 1822988노트

반응식

HRID 1822988 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[C:19](=[O:20])[CH2:18][CH:17]([C:21]([OH:23])=[O:22])[CH2:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O.Cl[CH2:30]Cl>CO>[CH3:30][O:22][C:21]([CH:17]1[CH2:18][C:19](=[O:20])[N:15]([C:12]2[CH:13]=[CH:14][C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:10][CH:11]=2)[CH2:16]1)=[O:23]

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 6344DichloromethaneHCID 2968114STK087815

생성물 1

HCID 10336428HCID 10336428, 화합물수율 93%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

7.46 g (24 mmol) (RS)-1-(4-benzyloxy-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid is dissolved in a mixture of 40 ml dichloromethane and 7.5 ml methanol. 0.13 ml concentrated sulfuric acid is added and the reaction mixture hold under reflux over night. The solvent is evaporated and the residue triturated with diethyl ether to yield 7.26 g (93%) of a colorless solid (used in the next step without further purification).

후처리

  1. temperaturethe reaction mixture hold under reflux over night
  2. customThe solvent is evaporated
  3. customthe residue triturated with diethyl ether

출처 및 근거

ORD 기록
ord-f7ec6f4ddd45480ebe88be10d5be8293
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07037935B2

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