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2,4,6-Trifluorobenzyl bromide → Methylamine

HRID 1822993
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HRID 1822993 반응식
COC(C1CC(=O)[N:7](C2C=CC(O)=CC=2)[CH2:6]1)=O.FC1C=C(F)C=C(F)C=1CBr.C[O:30][C:31]([CH:33]1[CH2:37][C:36](=[O:38])[N:35]([C:39]2[CH:44]=[CH:43][C:42]([O:45][CH2:46][C:47]3[C:52]([F:53])=[CH:51][C:50]([F:54])=[CH:49][C:48]=3[F:55])=[CH:41][CH:40]=2)[CH2:34]1)=O>>[CH3:6][NH2:7].[CH3:6][NH:7][C:31]([CH:33]1[CH2:37][C:36](=[O:38])[N:35]([C:39]2[CH:44]=[CH:43][C:42]([O:45][CH2:46][C:47]3[C:52]([F:53])=[CH:51][C:50]([F:54])=[CH:49][C:48]=3[F:55])=[CH:41][CH:40]=2)[CH2:34]1)=[O:30]
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 27770592,4,6-Trifluorobenzyl bromideHCID 2883518Methyl 1-(4-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylateHCID 68614540(RS)-5-oxo-1-[4-(2,4,6-trifluoro-benzyloxy)-phenyl]-pyrrolidine-3-carboxylic acid methyl ester

생성물 2

HCID 6329MethylamineHCID 10362262(RS)-5-oxo-1-[4-(2,4,6-trifluoro-benzyloxy)-phenyl]-pyrrolidine-3-carboxylic acid methylamide

실험 절차

The title compound is prepared by alkylation of the (RS)-1-(4-hydroxyphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester with 2,4,6-trifluorobenzyl bromide giving the (RS)-5-oxo-1-[4-(2,4,6-trifluoro-benzyloxy)-phenyl]-pyrrolidine-3-carboxylic acid methyl ester which, thereupon, by treatment with methylamine yields the (RS)-5-oxo-1-[4-(2,4,6-trifluoro-benzyloxy)-phenyl]-pyrrolidine-3-carboxylic acid methylamide. Yield: 97% of theory as a white solid. MS: m/e=379 (M+H)+.

출처 및 근거

ORD 기록
ord-8f4821d524f84460a6f309bab089be5b
출처 데이터셋
uspto-grants-2006_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07037935B2

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