Water → 4-Chloro-N-hydroxy-3-pyridinecarboximidoyl chloride

HRID 1823277노트

반응식

HRID 1823277 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[CH:8]=[N:9][OH:10].[Cl:11]N1C(=O)CCC1=O.O>CN(C)C=O>[Cl:11][C:8]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:2]=1[Cl:1])=[N:9][OH:10]

참가 물질

5

반응물 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 57365610HCID 57365610, 화합물

생성물 1

HCID 738675804-Chloro-N-hydroxy-3-pyridinecarboximidoyl chloride수율 75.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Dissolve 4-chloropyridine-3-carboxaldehyde oxime (2.60 g, 0.017 mol) in N,N-dimethylformamide (20 mL). Add N-chlorosuccinimide (2.48 g, 0.018 mol) in small portions and stir overnight at ambient temperature. Pour the mixture into water and extract with ethyl acetate. Wash the combined extracts with water and dry over sodium sulfate. Concentrate in vacuo to give 2.45 g (75%) of crude product as a yellowish solid. 1H NMR was consistent with structure.

후처리

  1. extractionextract with ethyl acetate
  2. washWash the combined extracts with water
  3. dry with materialdry over sodium sulfate
  4. concentrationConcentrate in vacuo

출처 및 근거

ORD 기록
ord-bfd19997605e4ea5a3112a30a94f813e
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07037921B2

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