2-Imidazoline → 1-(4-Ethylphenyl)-2-imidazolylethan-1-one

HRID 1823452

반응식

HRID 1823452 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH3:12])=[CH:7][CH:6]=1)=[O:4].[NH:13]1[CH2:17][CH2:16][N:15]=[CH:14]1>C(#N)C>[CH2:11]([C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][C:14]2[NH:13][CH:17]=[CH:16][N:15]=2)=[CH:6][CH:7]=1)[CH3:12]

참가 물질

4

반응물 2

HCID 681562-ImidazolineHCID 124019512-Bromo-1-(4-ethylphenyl)ethan-1-one

생성물 1

HCID 221425781-(4-Ethylphenyl)-2-imidazolylethan-1-one

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

실험 절차

1 mmol of 2-bromo-1-(4-ethylphenyl)ethan-1-one in acetonitrile was added drop wise to 5.5 mmol imidazoline in acetonitrile at room temperature for fourteen hours. The reaction mixture was concentrated in vacuo and diluted with water and ethyl acetate. The solution was extracted three times with ethyl acetate and dried over sodium sulfate to obtain 1-(4-ethylphenyl)-2-imidazolylethan-1-one.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additiondiluted with water and ethyl acetate
  3. extractionThe solution was extracted three times with ethyl acetate
  4. dry with materialdried over sodium sulfate

출처 및 근거

ORD 기록
ord-f9f5a92ea9be466096af4acb0a9610f2
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07037918B2

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