3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-5-carbonitrile → 3-[1-(8-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-1H-indole-5-carbonitrile

HRID 1823839

반응식

HRID 1823839 반응식
[NH:1]1[CH2:6][CH:5]=[C:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:16]#[N:17])[CH:14]=3)[NH:9][CH:8]=2)[CH2:3][CH2:2]1.[CH3:18][O:19][C:20]1[C:25]2[O:26][C@H:27]([CH2:30]C3C=C(C)C=CC=3S([O-])(=O)=O)[CH2:28][O:29][C:24]=2[CH:23]=[CH:22][CH:21]=1>CN(C)C=O.O1CCCC1.C(=O)(O)[O-].[Na+]>[CH3:18][O:19][C:20]1[C:25]2[O:26][CH:27]([CH2:30][N:1]3[CH2:2][CH:3]=[C:4]([C:7]4[C:15]5[C:10](=[CH:11][CH:12]=[C:13]([C:16]#[N:17])[CH:14]=5)[NH:9][CH:8]=4)[CH2:5][CH2:6]3)[CH2:28][O:29][C:24]=2[CH:23]=[CH:22][CH:21]=1

참가 물질

5

반응물 2

HCID 113335543-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-5-carbonitrileHCID 86586596(2R)-8-methoxy-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl-4-methylbenzenesulfonate

생성물 1

HCID 102723843-[1-(8-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-1H-indole-5-carbonitrile수율 56.6%

시약·촉매·용매 2

HCID 516892Sodium Bicarbonate용매HCID 21974620tetrahydrofuran N,N-dimethylformamide용매

실험 절차

3-(1,2,3,6-Tetrahydro-4-pyridinyl)1H-indole-5-carbonitrile (0.70 g, 3.1 mmole) and [(2R)-8-methoxy-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl-4-methylbenzenesulfonate (040 g, 1.1 mmole) were dissolved in a mixture of dimethylformamide/tetrahydrofuran (1:1 v/v, 50 mL) and sodium bicarbonate (1.0 g) added. The reaction mixture was refluxed under nitrogen for 18 hours. The solvent was evaporated in vacuum and the residue partitioned between 400 mL each of methylene chloride and water. The organic phase was separated, washed with water and saturated aqueous sodium chloride solution, dried over magnesium sulfate and filtered. The filtrate was evaporated in vacuum to give a solid which was purified by column chromatography on silica gel. Elution with 2% methanol in chloroform, concentration of the product fractions in vacuum and treatment of an ethereal solution of the residue with 4 N isopropanolic HCl gave the (S)-enantiomer of the title compound (250 mg, 54%) as a yellow solid hydrochloride, one-quarter hydrate, m.p. 235–238° C.

후처리

  1. additionadded
  2. temperatureThe reaction mixture was refluxed under nitrogen for 18 hours
  3. customThe solvent was evaporated in vacuum
  4. customthe residue partitioned between 400 mL each of methylene chloride and water
  5. customThe organic phase was separated
  6. washwashed with water and saturated aqueous sodium chloride solution
  7. dry with materialdried over magnesium sulfate
  8. filtrationfiltered
  9. customThe filtrate was evaporated in vacuum
  10. customto give a solid which
  11. customwas purified by column chromatography on silica gel
  12. washElution with 2% methanol in chloroform, concentration of the product fractions in vacuum and treatment of an ethereal solution of the residue with 4 N isopropanolic HCl

출처 및 근거

ORD 기록
ord-4590362463104371aeb602494c21595d
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07041683B2

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