5-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amine → 3,6-diethyl-N-(5-methoxy 1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine

HRID 1824093

반응식

HRID 1824093 반응식
[CH2:1]([C:3]1[C:4](N[C@@H]2C3C(=CC=CC=3)C[C@@H]2O)=[N:5][C:6]([CH2:9][CH3:10])=[CH:7][N:8]=1)[CH3:2].[CH3:22][O:23][C:24]1[CH:33]=[CH:32][CH:31]=[C:30]2[C:25]=1[CH2:26][CH2:27][CH2:28][CH:29]2[NH2:34]>>[CH2:1]([C:3]1[C:4]([NH:34][CH:29]2[C:30]3[C:25](=[C:24]([O:23][CH3:22])[CH:33]=[CH:32][CH:31]=3)[CH2:26][CH2:27][CH2:28]2)=[N:5][C:6]([CH2:9][CH3:10])=[CH:7][N:8]=1)[CH3:2]

참가 물질

3

반응물 2

HCID 388995-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amineHCID 58583341(1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol

생성물 1

HCID 221474773,6-diethyl-N-(5-methoxy 1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine

실험 절차

Following the procedure for the preparation of (1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol but substituting 5-methoxy-1,2,3,4-tetrahydronaphthalen-1-amine and making non-critical variations provided the title compound as a oil: 1H NMR (400 MHz, CDCl3) δ 7.66, 7.19, 7.00, 6.78, 5.47, 4.54, 3.87, 2.83, 2.68, 2.54, 2.06, 2.02, 1.97, 1.31; 13C NMR (100 MHz, CDCl3) δ 157.50, 153.66, 161.36, 140.81, 139.90, 129.80, 127.37, 126.82, 121.33, 108.49, 55.75, 48.72, 29.44, 28.55, 26.08, 23.59, 19.62, 13.93, 11.14; HRMS (FAB) calcd for C19H25N3O+H 312.2076, found 312.2066.

출처 및 근거

ORD 기록
ord-28438aa0993e4f3ca7a86029b1c36a58
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07041672B2

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