2-(((Tert-butoxy)carbonyl)amino)butanoic acid → Methyl({2-[(tert-butoxycarbonyl)amino]butanoyl}amino)(cyclopropyl)acetate

HRID 1824233노트

반응식

HRID 1824233 반응식
[CH3:1][O:2][C:3](=[O:21])[CH:4]([NH:8][C:9](=[O:20])[C@H:10]([CH3:19])[NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH:5]1[CH2:7][CH2:6]1.[C:22](NC(CC)C(O)=O)(OC(C)(C)C)=O>>[CH3:1][O:2][C:3](=[O:21])[CH:4]([NH:8][C:9](=[O:20])[CH:10]([NH:11][C:12]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:13])[CH2:19][CH3:22])[CH:5]1[CH2:6][CH2:7]1

참가 물질

3

반응물 2

HCID 3335222-(((Tert-butoxy)carbonyl)amino)butanoic acidHCID 58583288methyl{[N-(tert-butoxycarbonyl)-L-alanyl]amino}(cyclopropyl)acetate

생성물 1

HCID 23593721Methyl({2-[(tert-butoxycarbonyl)amino]butanoyl}amino)(cyclopropyl)acetate

실험 절차

Following the procedure for the preparation of methyl{[N-(tert-butoxycarbonyl)-L-alanyl]amino}(cyclopropyl)acetate but substituting N-Boc-alpha-aminobutyric acid and making non-critical variations provided the title compound as a solid: 1H NMR (CDCl3) δ 0.40–0.62, 0.94–0.99, 1.09–1.12, 1.46, 1.63–2.06, 3.77, 4.04, 5.02, 6.54.

출처 및 근거

ORD 기록
ord-db1416645b4b42dea92408133286df18
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07041672B2

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