3-Cyclopropyl-6-methylpiperazine-2,5-dione → 3-Cyclopropyl-6-ethylpiperazine-2,5-dione

반응식

C1(C2NC(=O)C(C)NC2=O)CC1.Cl.C[O:15][C:16](=O)[CH:17]([NH:21][C:22](=[O:27])[CH:23]([NH2:26])[CH2:24][CH3:25])[CH:18]1[CH2:20][CH2:19]1>>[CH:18]1([CH:17]2[NH:21][C:22](=[O:27])[CH:23]([CH2:24][CH3:25])[NH:26][C:16]2=[O:15])[CH2:20][CH2:19]1

참가 물질

반응물 2

HCID 221473683-Cyclopropyl-6-methylpiperazine-2,5-dione

HCID 86588881Methyl[(2-aminobutanoyl)amino](cyclopropyl)acetate hydrochloride

생성물 1

HCID 221475383-Cyclopropyl-6-ethylpiperazine-2,5-dione

실험 절차

Following the procedure for the preparation of 3-cyclopropyl-6-methylpiperazine-2,5-dione but substituting methyl[(2-aminobutanoyl)amino](cyclopropyl)acetate hydrochloride and making non-critical variations provided the title compound as a solid: 1H NMR (DMSO-d6) δ 0.29–0.48, 0.79–1.20, 1.69, 3.20, 3.93, 8.05.

출처 및 근거

ORD 기록: ord-739472e57ce6488392d8f0d063b3029f
출처 데이터셋: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07041672B2

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