Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine → 2-[4-(2-Hydroxy-3-propylaminopropoxy)phenyl]-8-methylimidazo[1,2-a]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine | HCID 22015632 | — |
| 용매 | Propylamine | HCID 7852 | — |
| 생성물 | 2-[4-(2-Hydroxy-3-propylaminopropoxy)phenyl]-8-methylimidazo[1,2-a]pyridine | HCID 22015604 | — |
반응 단계
The product of Step C (5.0 g) and propylamine (20 mL) was heated at 40° C. for 18 hours. The reaction was cooled to ambient temperature evaporated and the residue purified via silica gel chromatography (dichloromethane/methanol) to give the title compound which was converted to a HCl salt upon treatment with HCl/methanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07041828B2 |
| 출처 데이터셋 | uspto-grants-2006_05 |
| ORD ID | ord-b89a0f4cb6f043ba843623570e4eed85 |
| 출처 메모 | uspto-grants-2006_05 |