Epichlorohydrin → 2-[(4-Benzoylphenoxy)methyl]oxirane

HRID 1824666

반응식

HRID 1824666 반응식
[OH:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[CH2:16]([CH:18]1[O:20][CH2:19]1)Cl.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:16]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:14][CH:15]=1)[CH:18]1[O:20][CH2:19]1

참가 물질

5

반응물 3

HCID 7835EpichlorohydrinHCID 11430Potassium CarbonateHCID 143474-Hydroxybenzophenone

생성물 1

HCID 3528162-[(4-Benzoylphenoxy)methyl]oxirane

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

As illustrated in FIG. 6, 100 mL of dried acetone were added to a dry, 250-mL round bottom flask, equipped with a magnetic stirrer, along with 15.05 grams of 4-hydroxybenzophenone, 32.1 grams of epichlorohydrin, and 6.2 grams of potassium carbonate. The solution was heated to reflux for 6 hours and then cooled to room temperature. The precipitated potassium chloride was filtered off, and the solution was evaporated to remove excess epichlorohydrin. The crude product was recrystallized from methanol. 1H NMR data confirmed the formation of the desired product.

후처리

  1. additionwere added to a dry, 250-mL round bottom flask
  2. temperatureThe solution was heated
  3. temperatureto reflux for 6 hours
  4. filtrationThe precipitated potassium chloride was filtered off
  5. customthe solution was evaporated
  6. customto remove excess epichlorohydrin
  7. customThe crude product was recrystallized from methanol

출처 및 근거

ORD 기록
ord-11abb5634ed142ee9bd12b16b8fc0da6
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07045366B2

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