홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

7-Bromo-5-methoxy-2-(4-methoxyphenyl)-1,3-benzoxazole → HCID 22144541, 화합물

HRID 1824788
노트
인쇄 미리보기

반응식

HRID 1824788 반응식
Br[C:2]1[C:10]2[O:9][C:8]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[N:7][C:6]=2[CH:5]=[C:4]([O:19][CH3:20])[CH:3]=1.[C:21]([Cu])#[N:22]>CN(C=O)C.C(OCC)(=O)C>[CH3:20][O:19][C:4]1[CH:3]=[C:2]([C:21]#[N:22])[C:10]2[O:9][C:8]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[N:7][C:6]=2[CH:5]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 121489697-Bromo-5-methoxy-2-(4-methoxyphenyl)-1,3-benzoxazoleHCID 178418546HCID 178418546, 화합물

생성물 1

HCID 22144541HCID 22144541, 화합물수율 50.7%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

반응 조건

온도
150 °C

실험 절차

To 7-bromo-5-methoxy-2-(4-methoxy-phenyl)-benzooxazole (200 mg) in DMF (5 mL) was added CuCN (80 mg). The mixture was placed in an oil bath and heated to 150° C. for 3 h. The mixture was cooled to room temperature and diluted with ethyl acetate and washed with 1N HCl, brine (3×), dried (Na2SO4), and concentrated. Flash chromatography on silica gel eluting with 20% ethyl acetate-hexane afforded 85 mg (50%) of the title compound as a solid. MS: 281 (MH+), HPLC tR: 2.71 min.

후처리

  1. customThe mixture was placed in an oil bath
  2. temperatureThe mixture was cooled to room temperature
  3. washwashed with 1N HCl, brine (3×)
  4. dry with materialdried (Na2SO4)
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-655828843d404bc0a0387112ddefbeef
출처 데이터셋
uspto-grants-2006_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07045539B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트