Benzenesulfonamide, 3-nitro- → N-{3-[4-(1,2-diphenyl-but-1-enyl)-phenyl]-acryloyl}-3-nitro-benzenesulfonamide

HRID 1824873

반응식

HRID 1824873 반응식
[C:1]1(/[C:7](/[C:17]2[CH:22]=[CH:21][C:20]([CH:23]=[CH:24][C:25](O)=[O:26])=[CH:19][CH:18]=2)=[C:8](/[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)\[CH2:9][CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N+:28]([C:31]1[CH:32]=[C:33]([S:37]([NH2:40])(=[O:39])=[O:38])[CH:34]=[CH:35][CH:36]=1)([O-:30])=[O:29]>>[C:1]1([C:7]([C:17]2[CH:22]=[CH:21][C:20]([CH:23]=[CH:24][C:25]([NH:40][S:37]([C:33]3[CH:34]=[CH:35][CH:36]=[C:31]([N+:28]([O-:30])=[O:29])[CH:32]=3)(=[O:38])=[O:39])=[O:26])=[CH:19][CH:18]=2)=[C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:9][CH3:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

3

반응물 2

HCID 67138Benzenesulfonamide, 3-nitro-HCID 30361523-[4-(Z)-(1,2-diphenylbut-1-enyl)phenyl]-acrylic acid

생성물 1

HCID 69317494N-{3-[4-(1,2-diphenyl-but-1-enyl)-phenyl]-acryloyl}-3-nitro-benzenesulfonamide

실험 절차

Prepared by coupling 1a and 3-nitrobenzenesulfonamide in accordance with Procedure 1, Method A described hereinabove. Yield (14%); 1H NMR (d6-DMSO) δ 8.59 (t, J=2.2 Hz, 1H), 8.47 (d, J=7.0 Hz, 1H), 8.30 (d, J=7.7 Hz, 1H) 7.87 (t, J=8.1 Hz, 1H), 7.38–7.07 (m, 13H), 6.83 (d, J=8.4 Hz, 2H), 6.38 (d, J=15.7 Hz, 1H), 2.35 (q, J=7.4 Hz, 2H), 0.81 (t, J=7.4 Hz, 3H); APcI m/z: 537 (M−H−).

후처리

  1. customPrepared
  2. customYield (14%)

출처 및 근거

ORD 기록
ord-6b1160bed7954d28beea9acd820dbbfc
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07045540B2

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