HCID 60128540, 화합물 → (3R,4S)-3,4-Dimethoxypyrrolidine

HRID 1825065노트

반응식

HRID 1825065 반응식
C(OC([N:11]1[CH2:15][C@H:14]([O:16][CH3:17])[C@H:13]([O:18][CH3:19])[CH2:12]1)=O)C1C=CC=CC=1>CO.[Pd]>[CH3:19][O:18][C@H:13]1[C@@H:14]([O:16][CH3:17])[CH2:15][NH:11][CH2:12]1

참가 물질

4

반응물 1

HCID 60128540HCID 60128540, 화합물

생성물 1

HCID 20745983(3R,4S)-3,4-Dimethoxypyrrolidine수율 99%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a stirred solution of 3,4-cis-dimethoxy-pyrrolidine-1-carboxylic acid benzyl ester 5b (16.95 g, 63.9 mmole) in MeOH (150 ml) was added 10% Pd on C (1.3 g). The mixture was stirred under H2 balloon at room temperature for 3 hours and filtered through celite. The filtrate was concentrated, in vacuo, re-dissolved in CH2Cl2 and dried over Na2SO4. The solution was concentrated to give 8.3 g (99%) of a yellow oil. 1H NMR (300 MHz, CDCl3) δ 3.80 (2H, m), 3.47 (2H, bs), 3.41 (6H, s), 3.01 (2H, bs).

후처리

  1. filtrationfiltered through celite
  2. concentrationThe filtrate was concentrated, in vacuo
  3. dissolutionre-dissolved in CH2Cl2
  4. dry with materialdried over Na2SO4
  5. concentrationThe solution was concentrated

출처 및 근거

ORD 기록
ord-a01778b5a9b349cda91194f76f21d881
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07045528B2

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