Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Chloride → 5-(2,4-Difluoro-phenylsulfanyl)-2-methanesulfonyl-6-methoxy-quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | Bis(trifluoroacetoxy)iodobenzene | HCID 102317 | — |
| 반응물 | 2,4-Difluorobenzene-1-thiol | HCID 2737073 | — |
| 반응물 | 2-Methanesulfonyl-6-methoxy-quinoline | HCID 11253377 | — |
| 생성물 | 5-(2,4-Difluoro-phenylsulfanyl)-2-methanesulfonyl-6-methoxy-quinoline | HCID 9864712 | — |
반응 단계
A solution of 2-methanesulfonyl-6-methoxy-quinoline (237 mg , 1 mmole) and 2,4-difluorobenzenethiol (296 mg ,2 mmoles) was treated with PIFA (645 mg, 1. 5 mmoles) and stirred for 30 min. The solution was poured into dilute NaCl solution and extracted with ethyl acetate (EtOAc). The organic layer was dried (MgSO4) and evaporated. The resulting oil was crystallized to yield 5-(2,4-difluoro-phenylsulfanyl)-2-methanesulfonyl-6-methoxy-quinoline 101.; ([M+H]+)=382 The yield is typically 80–90%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07049325B2 |
| 출처 데이터셋 | uspto-grants-2006_05 |
| ORD ID | ord-c470e275b06741a19f93245f94353303 |
| 출처 메모 | uspto-grants-2006_05 |