Phthalimide → 2-(2-Oxocyclohexyl)isoindole-1,3-dione

HRID 1825910

반응식

Cl[CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=[O:8].[C:9]1(=[O:19])[NH:13][C:12](=[O:14])[C:11]2=[CH:15][CH:16]=[CH:17][CH:18]=[C:10]12>>[O:8]=[C:3]1[CH2:4][CH2:5][CH2:6][CH2:7][CH:2]1[N:13]1[C:9](=[O:19])[C:10]2[C:11](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:12]1=[O:14]

참가 물질

반응물 2

HCID 6809Phthalimide

HCID 132032-Chlorocyclohexanone

생성물 1

HCID 3226012-(2-Oxocyclohexyl)isoindole-1,3-dione

실험 절차

The amine required as precursor was prepared in accordance with GB1131191. 2-Chlorocyclohexanone was reacted with phthalimide to give 2-(2-oxocyclohexyl)isoindole-1,3-dione, which was ketalized with ethylene glycol in the presence of para-toluenesulfonic acid, giving 2-(1,4-dioxaspiro[4.5]dec-6-yl)isoindole-1,3-dione. Treatment with hydrazine hydrate to remove the phthalimideradical gave the desired 1,4-dioxaspiro[4.5]dec-6-ylamine. b) 1-(1,4-Dioxaspiro[4.5]dec-6-yl)-3-(4-methylthiophen-3-yl)thiourea

후처리

customwas prepared in accordance with GB1131191

출처 및 근거

ORD 기록: ord-70aa7ce828874231afd8bdcea217d897
출처 데이터셋: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07049333B2

연결된 노트

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