Triethylamine → HCID 22139808, 화합물
반응식
[C:1]([NH:4][C:5]1[C:9]([Cl:10])=[C:8](Cl)[S:7][C:6]=1[C:12]([O:14][CH3:15])=[O:13])(=[O:3])[CH3:2].C(N(CC)CC)C.[H][H]>[Pd].CO>[C:1]([NH:4][C:5]1[C:9]([Cl:10])=[CH:8][S:7][C:6]=1[C:12]([O:14][CH3:15])=[O:13])(=[O:3])[CH3:2]참가 물질
6
실험 절차
A mixture of 25 g of methyl 3-acetylamino-4,5-dichlorothiophene-2-carboxylate, about 10 g of triethylamine, 300 ml of methanol and 1 g of palladium on carbon is, at room temperature and under atmospheric pressure, hydrogenated until the uptake of hydrogen has stopped. The catalyst is filtered off and the mixture is then concentrated by distillation under reduced pressure until crystallization begins, water is then added and the solid is filtered off. Colorless crystals from isopropanol. M.p. 142-147° C.
후처리
- customis, at room temperature and under atmospheric pressure
- filtrationThe catalyst is filtered off
- concentrationthe mixture is then concentrated by distillation under reduced pressure until crystallization
- additionwater is then added
- filtrationthe solid is filtered off
출처 및 근거
- ORD 기록
- ord-865ae88bdb254a7886a2e23f40c0be52
- 출처 데이터셋
- uspto-grants-2006_05
- 특허 번호
- US07049333B2
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