Ethyl indole-2-carboxylate → 6-methoxy-1-methyl-1H-indole

반응식

[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH:7]=[CH:8][NH:9]2)=[CH:5][CH:4]=1.N1C2C(=CC=CC=2)C=[C:13]1C(OCC)=O>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH:7]=[CH:8][N:9]2[CH3:13])=[CH:5][CH:4]=1

참가 물질

반응물 2

HCID 73125Ethyl indole-2-carboxylate

HCID 766596-Methoxy-1H-indole

생성물 1

HCID 47779296-methoxy-1-methyl-1H-indole수율 95%

실험 절차

According to the procedure of Preparation 9 (a), except substituting 6-methoxy-1H-indole for the ethyl indole-2-carboxylate, the title compound (2.3 g, 95%) was obtained as an oil: MS (ES) m/e 162.2 (M+H)+.

출처 및 근거

ORD 기록: ord-6bf75116f8874949b6821c21b888cbc6
출처 데이터셋: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07049310B2

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