Ethyl indole-2-carboxylate → 6-Fluoro-1-methyl-1H-indole-3-carbaldehyde

반응식

[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:11]=[O:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.N1C2C(=CC=CC=2)C=[C:14]1C(OCC)=O>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:11]=[O:12])=[CH:7][N:8]2[CH3:14])=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 73125Ethyl indole-2-carboxylate

HCID 2629036-Fluoroindole-3-carboxaldehyde

생성물 1

HCID 64981976-Fluoro-1-methyl-1H-indole-3-carbaldehyde수율 94%

실험 절차

According to the procedure of Preparation 9 (a), except substituting 6-fluoro-1H-indole-3-carboxaldehyde (0.3 g, 1.8 mmole) for the ethyl indole-2-carboxylate, the title compound (0.3 g, 94%) was prepared as a viscous oil: MS (ES) m/e 178 (M+H)+.

출처 및 근거

ORD 기록: ord-9ec462ad40ea4996b27ff6fb94c369c1
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07741339B2

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