2,3-Dimethyl-6-methoxyindole → 2,3-Dimethyl-1H-indol-6-ol

HRID 1826217노트

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HRID 1826217 반응식
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[CH3:11])=[CH:8][CH:7]=[C:6]([O:12]C)[CH:5]=2.Cl.N1C=CC=CC=1>O>[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[CH3:11])=[CH:8][CH:7]=[C:6]([OH:12])[CH:5]=2

참가 물질

4

반응물 2

HCID 2665942,3-Dimethyl-6-methoxyindoleHCID 10176127Pyridinium chloride

생성물 1

HCID 221414062,3-Dimethyl-1H-indol-6-ol

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
200 °C

실험 절차

2,3-Dimethyl-6-methoxy-1H-indole (2.0 g; synthesized by the process reported by Ockenden et al., J. Chem. Soc., pp. 3175-3180 (1957)) was mixed with pyridine hydrochloride (7.91 g; mfd. by KANTO KAGAKU). The resulting mixture was stirred at 200° C. for 15 minutes and then cooled. After adding water (100 mL), the mixture was then extracted with ethyl acetate (100 mL). The organic layer was dried over anhydrous sodium sulfate (10 g). The solvent was distilled off under reduced pressure to yield crude 2,3-dimethyl-6-hydroxy-1H-indole (1.86 g) as a gray crystal.

후처리

  1. customsynthesized by the process
  2. temperaturecooled
  3. extractionthe mixture was then extracted with ethyl acetate (100 mL)
  4. dry with materialThe organic layer was dried over anhydrous sodium sulfate (10 g)
  5. distillationThe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-25317aea68bc4ed5b472ceaaaecbce39
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07049445B2

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