Formamidine acetate → 5,7-dimethoxyquinazolin-4(3H)-one
반응식
[NH2:1][C:2]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[C:8]([O:14][CH3:15])[C:3]=1[C:4](OC)=[O:5].C(O)(=O)C.[CH:20](N)=[NH:21]>COCCO>[CH3:15][O:14][C:8]1[CH:9]=[C:10]([O:12][CH3:13])[CH:11]=[C:2]2[C:3]=1[C:4](=[O:5])[NH:21][CH:20]=[N:1]2참가 물질
4
실험 절차
A mixture of methyl 2-amino-4,6-dimethoxybenzoate (16 g), formamidine acetate (24 g) and 2-methoxyethanol (330 ml) was stirred and heated to reflux until all of the starting material had reacted. The mixture was evaporated and the residue was triturated under water (100 ml). The resultant solid was isolated, washed with water and dried under vacuum to give 5,7-dimethoxy-3,4-dihydroquinazolin-4-one (14.5 g); NMR Spectrum: (DMSOd6) 3.82 (s, 3H), 3.86 (s, 3H), 6.5 (s, 1H), 6.7 (s, 1H), 7.9 (s, 1H), 11.7 (br s, 1H).
후처리
- temperatureheated
- temperatureto reflux until all of the starting material
- customhad reacted
- customThe mixture was evaporated
- customthe residue was triturated under water (100 ml)
- customThe resultant solid was isolated
- washwashed with water
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-e1b2d9700060491b95fddc6fae46ead2
- 출처 데이터셋
- uspto-grants-2006_05
- 특허 번호
- US07049438B2
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