2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, hydrochloride, (S)- → Timolol

HRID 1826578노트

반응식

HRID 1826578 반응식
[CH3:1][C:2]([NH:5][CH2:6][C@H:7]([OH:21])[CH2:8][O:9][C:10]1[C:11]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[N:12][S:13][N:14]=1)([CH3:4])[CH3:3].Cl>C([O-])(=O)C>[CH3:4][C:2]([NH:5][CH2:6][C@H:7]([OH:21])[CH2:8][O:9][C:10]1[C:11]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[N:12][S:13][N:14]=1)([CH3:1])[CH3:3]

참가 물질

3

반응물 1

HCID 1552082-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, hydrochloride, (S)-

생성물 1

HCID 33624Timolol

시약·촉매·용매 1

HCID 175Acetate용매

실험 절차

Timolol HCl (3-tert-butylamino-1-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol) is a beta-blocker for treatment of glaucoma. The drug is dissolved in a final concentration of 0.5% (m/v) in 20 mM acetate buffer pH 5.2. After the addition of chitosan-4-thio-butyl-amidine conjugate in a final concentration of 0.1% (m/v) and a preservative in a final concentration of 0.03% (m/v), the pH-value is readjusted to pH 5.2. Remaining oxygen is removed by bubbling the solution with nitrogen. The resulting eye drops are filled up under inert conditions in multiple unit vessels of 10 ml. The vessels are than sealed with an aluminium-foil.

후처리

  1. customRemaining oxygen is removed
  2. customby bubbling the solution with nitrogen
  3. additionThe resulting eye drops are filled up under inert conditions in multiple unit vessels of 10 ml
  4. customthan sealed with an aluminium-foil

출처 및 근거

ORD 기록
ord-ac5a061bae6440cf8c1547d75a44897e
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07053068B2

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