Dimethyl Sulfide → 4-(2-Hydroxybenzyl)phenylacetonitrile

HRID 1826631노트

반응식

HRID 1826631 반응식
FC(F)(F)C(O)=O.CSC.C([O:18][C:19]1[CH:34]=[CH:33][CH:32]=[CH:31][C:20]=1[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29]#[N:30])=[CH:24][CH:23]=1)C1C=CC=CC=1>O>[OH:18][C:19]1[CH:34]=[CH:33][CH:32]=[CH:31][C:20]=1[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29]#[N:30])=[CH:24][CH:23]=1

참가 물질

5

반응물 3

HCID 1068Dimethyl SulfideHCID 6422Trifluoroacetic acidHCID 21909295[4-(2-Benzyloxybenzyl)phenyl]acetonitrile

생성물 1

HCID 219092754-(2-Hydroxybenzyl)phenylacetonitrile수율 89%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Trifluoroacetic acid (17 mL), water (1 mL) and dimethyl sulfide (2 mL) were added to [4-(2-benzyloxybenzyl)phenyl]-acetonitrile (0.41 g), and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate=3/1) to give [4-(2-hydroxybenzyl)phenyl]acetonitrile (0.26 g).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate=3/1)

출처 및 근거

ORD 기록
ord-72b55674f2a24e33ba0b885fe3037614
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07053060B2

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