4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine → (1H-Benzoimidazol-4-yl)-[6-(4-trifluoromethylphenyl)pyrimidin-4-yl]amine

HRID 1826810

반응식

HRID 1826810 반응식
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:5]=[CH:4][N:3]=1.[NH2:18][C:19]1[C:27]2[NH:26][CH:25]=[N:24][C:23]=2[CH:22]=[CH:21][CH:20]=1>>[NH:24]1[C:23]2[CH:22]=[CH:21][CH:20]=[C:19]([NH:18][C:2]3[CH:7]=[C:6]([C:8]4[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=4)[N:5]=[CH:4][N:3]=3)[C:27]=2[N:26]=[CH:25]1

참가 물질

3

반응물 2

HCID 167478374-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidineHCID 178507452HCID 178507452, 화합물

생성물 1

HCID 9820006(1H-Benzoimidazol-4-yl)-[6-(4-trifluoromethylphenyl)pyrimidin-4-yl]amine

실험 절차

Analogous to the procedure used to prepare Example 5(b), 4-chloro-6-(4-trifluoromethylphenyl)pyrimidine, Example 5(a), (690 mg, 2.67 mmol) and 4-aminobenzimidazole (296 mg, 2.22 mmol, Astatech) afforded after purification by silica gel chromatography with gradient from 1% to 10% solution of (2 M NH3 in MeOH) in CH2Cl2, the title compound as a yellow solid. MS (ESI, pos. ion.) m/z: 356 (M+1).

후처리

  1. customafforded
  2. customafter purification by silica gel chromatography with gradient from 1% to 10% solution of (2 M NH3 in MeOH) in CH2Cl2

출처 및 근거

ORD 기록
ord-b0f22b743d85423cb3754845f2026d16
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07053088B2

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