Pyridine → n-[(s)-2-Phenyl-1-propyl]-2-quinoxalinecarboxamide

HRID 1826883노트

반응식

HRID 1826883 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][C:2]=1[C:11](Cl)=[O:12].[C:14]1([C@H:20]([CH3:23])[CH2:21][NH2:22])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.N1C=CC=CC=1>O>[C:14]1([C@H:20]([CH3:23])[CH2:21][NH:22][C:11]([C:2]2[CH:3]=[N:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=2)=[O:12])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 1547950(2S)-2-Phenylpropan-1-amineHCID 2734681Quinoxaline-2-carbonyl chloride

생성물 1

HCID 9457046n-[(s)-2-Phenyl-1-propyl]-2-quinoxalinecarboxamide수율 74.9%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Prepared from 2-quinoxaloyl chloride (0.47 g, 2.4 mmol), (S)-2-phenyl-1-propylamine (0.30 g, 2.2 mmol), pyridine (5 mL), and water (50 mL) yielding 0.48 g (74%) of (173):

출처 및 근거

ORD 기록
ord-14f2d11297314c65991e91669bddc528
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07053104B2

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