7H-Purine, 6-chloro-7-methyl- → (7-Methyl-7H-purin-6-yl)-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amine

HRID 1827193노트

반응식

HRID 1827193 반응식
[C:1]1([CH2:7][CH2:8][S:9]([N:12]2[CH2:17][CH2:16][CH:15]([CH2:18][NH2:19])[CH2:14][CH2:13]2)(=[O:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:21]1[N:29]=[CH:28][N:27]=[C:26]2[C:22]=1[N:23]([CH3:30])[CH:24]=[N:25]2>>[CH3:30][N:23]1[C:22]2[C:26](=[N:27][CH:28]=[N:29][C:21]=2[NH:19][CH2:18][CH:15]2[CH2:14][CH2:13][N:12]([S:9]([CH2:8][CH2:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)(=[O:10])=[O:11])[CH2:17][CH2:16]2)[N:25]=[CH:24]1

참가 물질

3

반응물 2

HCID 950577H-Purine, 6-chloro-7-methyl-2회HCID 22135729[1-(2-Phenylethylsulfonyl)piperidin-4-yl]methanamine

생성물 1

HCID 23577259(7-Methyl-7H-purin-6-yl)-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amine

실험 절차

EXAMPLE 85 was prepared from C-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-methylamine and 6-chloro-7-methyl-7H-purine (6-chloro-7-methyl-7H-purine was prepared according to G. B. Eilon, J. Org. Chem., 27:2478–2491 (1962): MS (m+1)=415.

후처리

  1. customwas prepared

출처 및 근거

ORD 기록
ord-08a418cef8fe41a097c34e11ffa0aa17
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07053089B2

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