Methyl malonyl chloride → N-[4-(4-Trifluoromethyl-benzyloxy)-phenyl]-malonamic Acid Methyl Ester

HRID 1827379노트

반응식

HRID 1827379 반응식
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:17]=[CH:16][C:6]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[CH3:20][O:21][C:22](=[O:27])[CH2:23][C:24](Cl)=[O:25]>>[CH3:20][O:21][C:22](=[O:27])[CH2:23][C:24]([NH:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]2[CH:16]=[CH:17][C:3]([C:2]([F:18])([F:19])[F:1])=[CH:4][CH:5]=2)=[CH:10][CH:11]=1)=[O:25]

참가 물질

3

반응물 2

HCID 123460Methyl malonyl chlorideHCID 221378894-(4-Trifluoromethyl-benzyloxy)-phenylamine

생성물 1

HCID 69007555N-[4-(4-Trifluoromethyl-benzyloxy)-phenyl]-malonamic Acid Methyl Ester수율 71%

실험 절차

In analogy to example 1, the title compound is prepared from 4-(4-trifluoromethyl-benzyloxy)-phenylamine and chlorocarbonyl-acetic acid methyl ester. Yield: 71%. Colorless solid. MS: m/e=368.1 (M++H).

출처 및 근거

ORD 기록
ord-fda1cb098c974422ae6b8cc1245e8946
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07053245B2

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