Ammonium Hydroxide → HCID 22137939, 화합물

HRID 1827384노트

반응식

C[O:2][C:3](=O)[CH2:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=2)=[CH:10][C:9]=1[F:23])=[O:6].[OH-].[NH4+:26]>>[F:23][C:9]1[CH:10]=[C:11]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=2)[CH:12]=[CH:13][C:8]=1[NH:7][C:5](=[O:6])[CH2:4][C:3]([NH2:26])=[O:2]

참가 물질

반응물 2

HCID 14923Ammonium Hydroxide

HCID 9997061HCID 9997061, 화합물

생성물 1

HCID 22137939HCID 22137939, 화합물수율 87%

실험 절차

The title compound is prepared in analogy to example 3 from N-[2-fluoro-4-(3-fluoro-benzyloxy)-phenyl]-malonamic acid methyl ester and ammonium hydroxide. Yield=87%. Slightly yellow solid. MS: m/e=321.3 (M++H).

출처 및 근거

ORD 기록: ord-1a7a8e6baf2440248276a5e6dbf4f13a
출처 데이터셋: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07053245B2

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