Ammonium Hydroxide → N-[4-(3-Fluoro-phenoxymethyl)-phenyl]-malonamide

반응식

C[O:2][C:3](=O)[CH2:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][O:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=2)=[CH:10][CH:9]=1)=[O:6].[OH-].[NH4+:25]>>[F:22][C:18]1[CH:17]=[C:16]([CH:21]=[CH:20][CH:19]=1)[O:15][CH2:14][C:11]1[CH:12]=[CH:13][C:8]([NH:7][C:5](=[O:6])[CH2:4][C:3]([NH2:25])=[O:2])=[CH:9][CH:10]=1

참가 물질

반응물 2

HCID 14923Ammonium Hydroxide

HCID 69006710N-[4-(3-Fluoro-phenoxymethyl)-phenyl]-malonamic Acid Methyl Ester

생성물 1

HCID 22137978N-[4-(3-Fluoro-phenoxymethyl)-phenyl]-malonamide수율 37%

실험 절차

The title compound is prepared in analogy to example 3 from N-[4-(3-Fluoro-phenoxymethyl)-phenyl]-malonamic acid methyl ester and and ammonium hydroxide. Yield=37%. Colorless solid. MS: m/e=303.2 (M++H).

출처 및 근거

ORD 기록: ord-7a58fbf1e58e4f058021e506f56113b4
출처 데이터셋: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07053245B2

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