4-Ethyl-2-methylpyridine → HCID 11742250, 화합물

HRID 1827466노트

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HRID 1827466 반응식
C([C:3]1[CH:4]=[CH:5][C:6]([CH:9]=[CH:10][C:11]2[C:19]3[C:14](=[CH:15][C:16]([NH:20][C:21]4[CH:32]=[CH:31][CH:30]=[CH:29][C:22]=4[C:23]([NH:25][CH2:26][C:27]#[CH:28])=[O:24])=[CH:17][CH:18]=3)[NH:13][N:12]=2)=[N:7][CH:8]=1)C.[CH2:33](C1C=CN=C(C)C=1)C.ClC1C=C2C(C(C(O)CC3C=CC(CC)=CN=3)=NN2)=CC=1.C1(N)CC1>>[CH:26]1([NH:25][C:23](=[O:24])[C:22]2[CH:29]=[CH:30][CH:31]=[CH:32][C:21]=2[NH:20][C:16]2[CH:15]=[C:14]3[C:19]([C:11](/[CH:10]=[CH:9]/[C:6]4[CH:5]=[C:4]([CH3:33])[CH:3]=[CH:8][N:7]=4)=[N:12][NH:13]3)=[CH:18][CH:17]=2)[CH2:27][CH2:28]1

참가 물질

5

반응물 4

HCID 683074-Ethyl-2-methylpyridineHCID 69828CyclopropylamineHCID 86594461HCID 86594461, 화합물HCID 178436305HCID 178436305, 화합물

생성물 1

HCID 11742250HCID 11742250, 화합물

실험 절차

The title compound was prepared analogously to 2-{3-[2-(5-Ethyl-pyridin-2-yl)-vinyl]-1H-indazol-6-ylamino}-N-prop-2-ynyl-benzamide described above, substituting 2,4-dimethyl-pyridine for 4-ethyl-2-methyl-pyridine in the step where 1-(6-Chloro-1H-indazol-3-yl)-2-(5-ethyl-pyridin-2-yl)-ethanol was prepared, and substituting cyclopropyl amine in place of propargyl amine in the final step of the sequence. 1H NMR (DMSO-d6): δ 9.85 (1H, s), 8.56 (2H, m), 8.20 (3H, m), 7.53 (5H, m), 7.35 (1H, s), 7.2 (1H, d, J=6.5 Hz), 7.0 (1H, s), 2.83 (1H, m), 0.70 (2H, m), 0.56 (2H, m). ESIMS (M+H+): 410.3.

후처리

  1. customwas prepared

출처 및 근거

ORD 기록
ord-02603cba891b4f45af70d1b2575d2d08
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07053107B2

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