HCID 22136507, 화합물 → HCID 69353514, 화합물

HRID 1827485노트

반응식

HRID 1827485 반응식
[C:1]([Si:5]([CH3:13])([CH3:12])[O:6][CH2:7][C:8]#[C:9][CH2:10][NH2:11])([CH3:4])([CH3:3])[CH3:2].[CH3:14][C:15]1[CH:20]=[C:19]([CH3:21])[N:18]=[C:17]([CH:22]=[CH:23][C:24]2[C:32]3[C:27](=[CH:28][C:29]([NH:33][C:34]4[CH:42]=[CH:41][CH:40]=[CH:39][C:35]=4[C:36](O)=[O:37])=[CH:30][CH:31]=3)[N:26]([CH:43]3[CH2:48][CH2:47][CH2:46][CH2:45][O:44]3)[N:25]=2)[CH:16]=1>O>[C:1]([Si:5]([CH3:13])([CH3:12])[O:6][CH2:7][C:8]#[C:9][CH2:10][NH:11][C:36](=[O:37])[C:35]1[CH:39]=[CH:40][CH:41]=[CH:42][C:34]=1[NH:33][C:29]1[CH:28]=[C:27]2[C:32]([C:24]([CH:23]=[CH:22][C:17]3[CH:16]=[C:15]([CH3:14])[CH:20]=[C:19]([CH3:21])[N:18]=3)=[N:25][N:26]2[CH:43]2[CH2:48][CH2:47][CH2:46][CH2:45][O:44]2)=[CH:31][CH:30]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 22136507HCID 22136507, 화합물HCID 69353735HCID 69353735, 화합물

생성물 1

HCID 69353514HCID 69353514, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Prepared in a similar manner to that described for Example 33(a) step (v), in U.S. Pat. No. 6,531,491, issued Mar. 11, 2003, herein incorporated by reference in its entirety for all purposes, except using 4-(tert-Butyl-dimethyl-silanyloxy)-but-2-ynylamine and 2-[3-[2-(4,6-Dimethyl-pyridin-2-yl)-vinyl]-1-(tetrahydro-pyran-2-yl)-1H-indazol-6-ylamino]-benzoic acid. 1H NMR (DMSO-d6) δ 9.56 (1H, s), 9.01 (1H, t, J=5.7 Hz), 8.06 (1H, d, J=8.7 Hz), 7.81 (1H, d, J=16.4 Hz), 7.66 (1H, d, J=7.5 Hz), 7.41 (4H, m), 7.32 (1H, s), 7.09 (1H, dd, J=1.8, 8.7 Hz), 6.98 (1H, s), 6.89 (1H, t, J=8.0 Hz), 5.79 (1H, dd, J=2.4, 9.2 Hz), 4.28 (2H, s), 4.09 (2H, m), 3.86(1H,m), 3.72 (1H, m), 2.46 (3H, s), 2.42 (1H, m), 2.30 (3H, s), 2.08 (2H, m), 1.74 (1H, m), 1.57 (2H, m), 0.80 (9H, s), 0.03 (6H, s). Anal. Calcd for C38H47N5O3Si. 0.7 H2O: C, 68.89; H, 7.36; N, 10.57. Found: C, 68.99; H, 7.36; N, 10.21.

후처리

  1. customPrepared in a similar manner to that

출처 및 근거

ORD 기록
ord-f979418135414112b2dd9cf0c23e8153
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07053107B2

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