1,3-Dimethyl-1H-pyrazole-5-carbonitrile → (1,3-Dimethyl-1H-pyrazol-5-yl)methanamine

HRID 1827504노트

반응식

HRID 1827504 반응식
[CH3:1][N:2]1[C:6]([C:7]#[N:8])=[CH:5][C:4]([CH3:9])=[N:3]1>[Pd].C(O)C>[CH3:1][N:2]1[C:6]([CH2:7][NH2:8])=[CH:5][C:4]([CH3:9])=[N:3]1

참가 물질

4

반응물 1

HCID 27362971,3-Dimethyl-1H-pyrazole-5-carbonitrile

생성물 1

HCID 1257670(1,3-Dimethyl-1H-pyrazol-5-yl)methanamine수율 90%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A suspension of 2,5-Dimethyl-2H-pyrazole-3-carbonitrile (654 mg, 5.4 mmol) and 10% palladium on carbon (200 mg) in ethanol (15 mL) was shaken in a Parr hydrogenation apparatus under 45 psi H2 for 17 hr. The mixture was filtered through celite and the filtrate was concentrated under reduced pressure to give 608 mg of an oil which was used without any further purification. 1H NMR (CDCl3) δ 5.91 (1H, s), 3.81, 3.73 (2H,2s), 3.75 (3H, s), 2.21 (3H, s).

후처리

  1. filtrationThe mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-5774c3dfd7d147e1ba0495209d37260a
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07053107B2

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