Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Ether → Heptanoic acid, 6-oxo-, methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 6-Oxoheptanoic acid | HCID 98810 | — |
| 반응물 | 1-Methyl-2-nitro-1-nitrosoguanidine | HCID 9562060 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Heptanoic acid, 6-oxo-, methyl ester | HCID 288022 | — |
반응 단계
To a rapidly stirred mixture of diethyl ether (175 ml) and 40% KOH (52 ml) at 0° C. was added MNNG (15.4 g, 105 mmol). The mixture was stirred for 10 minutes. The ethereal layer was transferred to a solution of 6-oxo-heptanoic acid 1-1 (5.0 g, 34.68 mmol) and CH2Cl2 at 0° C. The solution was purged with argon for 30 minutes and then concentrated. Flash chromatography (silica, 30–50% EtOAc/hexanes) gave ester 1-2 as a clear oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07056909B2 |
| 출처 데이터셋 | uspto-grants-2006_06 |
| ORD ID | ord-b568aee39c274c39b556d1c29cb3a1d5 |
| 출처 메모 | uspto-grants-2006_06 |