Potassium Carbonate → 3-(2-Methyl-pyrimidin-5-yl)-7-oxo-9-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-non-5-enoic acid ethyl ester

HRID 1827685노트

반응식

HRID 1827685 반응식
COP([CH2:7][C:8](=[O:21])[CH2:9][CH2:10][C:11]1[CH:20]=[CH:19][C:18]2[CH2:17][CH2:16][CH2:15][NH:14][C:13]=2[N:12]=1)(=O)OC.[CH2:22]([O:24][C:25](=[O:38])[CH2:26][CH:27]([C:31]1[CH:32]=[N:33][C:34]([CH3:37])=[N:35][CH:36]=1)[CH2:28][CH:29]=O)[CH3:23].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[CH2:22]([O:24][C:25](=[O:38])[CH2:26][CH:27]([C:31]1[CH:32]=[N:33][C:34]([CH3:37])=[N:35][CH:36]=1)[CH2:28][CH:29]=[CH:7][C:8](=[O:21])[CH2:9][CH2:10][C:11]1[CH:20]=[CH:19][C:18]2[CH2:17][CH2:16][CH2:15][NH:14][C:13]=2[N:12]=1)[CH3:23]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 22082659[2-Oxo4-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-butyl]-phosphonic acid dimethyl esterHCID 235812803-(2-Methyl-pyrimidin-5-yl)-5-oxo-pentanoic acid ethyl ester

생성물 1

HCID 693721393-(2-Methyl-pyrimidin-5-yl)-7-oxo-9-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-non-5-enoic acid ethyl ester

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
50 °C

실험 절차

To a mixture of 4-10 (100 mg, 0.42 mmol) and 4-6 (160 mg, 0.54 mmol) in DMF (3 mL) was added K2CO3 (87 mg, 0.63 mmol) followed by heating to 50° C. for 18 hours. Following evaporative removal of the solvent, the residue was chromatographed (silica gel, 70:25:5 CHCl3/EtOAc/MeOH) to give 4-11 as a clear oil.

후처리

  1. customremoval of the solvent
  2. customthe residue was chromatographed (silica gel, 70:25:5 CHCl3/EtOAc/MeOH)

출처 및 근거

ORD 기록
ord-19a250a590354e3a898edbcb4e9141c1
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07056909B2

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