Methylamine → 5-[5-(4-Aminobutyl)pyridin-2-YL]-N-methylpentanamide
반응식
C(O[C:4](=[O:30])[CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][N:19]2C(=O)C3C(=CC=CC=3)C2=O)=[CH:11][N:10]=1)C.[CH3:31][NH2:32]>CO>[CH3:31][NH:32][C:4](=[O:30])[CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH2:19])=[CH:11][N:10]=1참가 물질
4
실험 절차
A mixture of 5-6 (45 g, 110 mmol) and a saturated solution of methylamine in methanol (300 mL) in a sealed tube was heated at 70° C. for 12 hours. The mixture was cooled and concentrated to an oil. The residue was chromatographed on silica gel (10:10:1:1 EtOAc/EtOH/NH4OH/H2O) to give 5-7 as a yellow oil.
후처리
- temperatureThe mixture was cooled
- concentrationconcentrated to an oil
- customThe residue was chromatographed on silica gel (10:10:1:1 EtOAc/EtOH/NH4OH/H2O)
출처 및 근거
- ORD 기록
- ord-37f2b9e6c9534f3fb109cf851d906005
- 출처 데이터셋
- uspto-grants-2006_06
- 특허 번호
- US07056909B2
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