Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl (R)-(+)-2-isocyanato-3-phenylpropionate → (R)-2-(4-Phenethyloxybenzyloxycarbonylamino)-3-phenyl-propionic Acid Methyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl (R)-(+)-2-isocyanato-3-phenylpropionate | HCID 6558897 | — |
| 반응물 | HCID 12990905 | HCID 12990905 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 생성물 | (R)-2-(4-Phenethyloxybenzyloxycarbonylamino)-3-phenyl-propionic Acid Methyl Ester | HCID 12990906 | 96.9% |
반응 단계
(4-Phenethyloxyphenyl)methanol 11(1.141 g, 5.0 mmol), (R)-2-isocyanato-3-phenyl-propionic acid methyl ester 5 (1.036 g, 5.0 mmol) and DMAP (10 mg) were combined and heated until molten and stirred for 20 min. Upon cooling the residue was purified by chromatography to give about 2.1 g of (R)-2-(4-phenethyloxybenzyloxycarbonylamino)-3-phenyl-propionic acid methyl ester 12.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07056903B2 |
| 출처 데이터셋 | uspto-grants-2006_06 |
| ORD ID | ord-297e07fca4964b65b847648f9925b19f |
| 출처 메모 | uspto-grants-2006_06 |