Potassium Carbonate → (5-Phenyl-benzoxazol-2-yl)methanol

HRID 1827990노트

반응식

HRID 1827990 반응식
[C:1]1([C:7]2[CH:8]=[CH:9][C:10]3[O:14][C:13]([CH2:15][O:16]C(=O)C)=[N:12][C:11]=3[CH:20]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([O-])([O-])=O.[K+].[K+]>CO>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]3[O:14][C:13]([CH2:15][OH:16])=[N:12][C:11]=3[CH:20]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 20622383Acetic Acid 5-phenyl-benzoxazol-2-ylmethyl Ester

생성물 1

HCID 22062842(5-Phenyl-benzoxazol-2-yl)methanol수율 72.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Acetic acid (5-phenyl-benzoxazol-2-yl)methyl ester 50 (409 mg, 1.53 mmol) was dissolved in 10 ml of methanol. Finely ground K2CO3 (53 mg, 0.38 mmol) was added. After 3 hrs, the mixture was concentrated then diluted with water and extracted with ethyl acetate. The extracts were washed with brine, dried, filtered and concentrated to yield about 251 mg of (5-phenyl-benzoxazole-2-yl)methanol 51.

후처리

  1. concentrationthe mixture was concentrated
  2. additionthen diluted with water
  3. extractionextracted with ethyl acetate
  4. washThe extracts were washed with brine
  5. customdried
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b568d62fd2124687a428fd93d365a9fb
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07056903B2

반응 노트

불러오는 중…