2-Benzylideneamino-4-methylphenol → 2-Phenyl-5-methylbenzoxazole

HRID 1827993

반응식

HRID 1827993 반응식
[CH:1](=[N:8][C:9]1[CH:14]=[C:13]([CH3:15])[CH:12]=[CH:11][C:10]=1[OH:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1(C)C=CC=CC=1.O.O.C([O-])(=O)C.[Mn+3].C([O-])(=O)C.C([O-])(=O)C>[CH3:15][C:13]1[CH:12]=[CH:11][C:10]2[O:16][C:1]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[N:8][C:9]=2[CH:14]=1

참가 물질

4

반응물 1

HCID 112987892-Benzylideneamino-4-methylphenol

생성물 1

HCID 819192-Phenyl-5-methylbenzoxazole수율 93.3%

시약·촉매·용매 2

HCID 12416832Manganese triacetate dihydrate촉매HCID 1140Toluene용매

실험 절차

A mixture of 2-benzylideneamino-4-methylphenol 54 (1.34g, 6.3 mmol) and manganese (III) acetate dihydrate (3.4 g, 12.7 mmol) in toluene (65 ml) was heated at reflux under an atmosphere of N2 for 1 hr and cooled to room temperature. The mixture was filtered to remove the insoluble manganese salts. The filtrate was evaporated under reduced pressure. The residue was taken up in methylene chloride and purified by filtration to yield 1.23 g 5-methyl-2-phenylbenzoxazole 55.

후처리

  1. temperaturewas heated
  2. temperatureat reflux under an atmosphere of N2 for 1 hr
  3. filtrationThe mixture was filtered
  4. customto remove the insoluble manganese salts
  5. customThe filtrate was evaporated under reduced pressure
  6. filtrationpurified by filtration

출처 및 근거

ORD 기록
ord-f78c79d4103444c8b2a1366a98344f45
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07056903B2

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