Thionyl Chloride → HCID 22063674, 화합물

반응식

[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]2[N:12]=[N:11][C:10]([CH2:13][C:14](O)=[O:15])=[N:9]2)=[CH:5][CH:4]=1.S(Cl)([Cl:21])=O>>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]2[N:12]=[N:11][C:10]([CH2:13][C:14]([Cl:21])=[O:15])=[N:9]2)=[CH:5][CH:4]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 22063596HCID 22063596, 화합물2회

생성물 1

HCID 22063674HCID 22063674, 화합물수율 96.4%

실험 절차

The 2-[2-(4-methoxybenzyl)-2H-1,2,3,4-tetrazol-5-yl]acetic acid (262.0 mg, 1.05 mmol) obtained in (B) was added dropwise with thionyl chloride (615.9 μl, 8.44 mmol) under ice cooling and stirred at room temperature for 30 minutes. Excessive regents were evaporated to obtain the title compound (0.27 g, quantitative) as pale yellow oil.

후처리

customExcessive regents were evaporated

출처 및 근거

ORD 기록: ord-08b46b59e2174ea58b9815c8042100ae
출처 데이터셋: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07056917B2

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