HCID 69603267, 화합물 → HCID 69603327, 화합물
반응식
[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:44]=[CH:43][N:14]3[C:15](=[O:42])[C:16]([C:25](=[O:41])[CH2:26][C:27]4[N:28]=[N:29][N:30](CC5C=CC(OC)=CC=5)[N:31]=4)=[C:17]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]>FC(F)(F)C(O)=O>[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:44]=[CH:43][N:14]3[C:15](=[O:42])[C:16]([C:25](=[O:41])[CH2:26][C:27]4[N:28]=[N:29][NH:30][N:31]=4)=[C:17]([N:19]4[CH2:20][CH2:21][O:22][CH2:23][CH2:24]4)[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]참가 물질
3
실험 절차
The 8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-3-{2-[2-(4-methoxybenzyl)-2H -1,2,3,4-tetrazol-5-yl]acetyl}-2-morpholino-4 H-pyrido[1,2-a]pyrimidin-4-one (8.9 mg, 0.014 mmol) obtained in (D) was dissolved in trifluoroacetic acid (5 ml)and stirred at room temperature for 18 hours. The solvent was evaporated, and the residue was purified by preparative TLC (chloroform:methanol=10:1, v/v) and lyophilized from dioxane to obtain the title compound (4.8 mg, 67.0%) as pale yellow powder.
후처리
- customThe solvent was evaporated